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psychotherapy

How Psychotherapy Changes Your Brain

April 10, 2018

3 Min Read

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Written by: Dr. Lewis
Reviewed by: Hayden
Updated: July 7, 2025

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Home / Blogs / How Psychotherapy Changes Your Brain

The Brain and Therapy

For the millions of Americans who are battling mental health disorders, the choice between psychotherapy and psychiatric medications can be a challenging decision. Both methods have merit and track records of success – and certainly both have the same end goal: improving your life. The simple fact is that medication and therapy accomplish these objective by different means – one creates a biochemical change and the other a change in how we think, yet both work on the physical substrate of our brain and result in detectable changes in brain function and structure.

So, if you’re considering which route might be best for you, an important question comes to light: Are changes in the brain resulting from psychotherapy the same or different from changes induced by medications?

three trees in a line in the shape of faces with them being green, yellow and red with the red having the most leaves out of it and the green having all its leaves with the yellow one somewhere in the middle

A recent meta-analysis reveals that talk therapy and medications definitely affect the brain in different ways, but with a complementary effect. Researchers examined results from more than 30 different studies involving patients treated with commonly prescribed SSRIs and 18 studies that focused on individuals who underwent psychotherapy. In comparing brain activity before and after treatment, results revealed some significant differences.

The medication treatments were found to have the most impact on the areas of the brain connected to emotional processing and psychosomatic symptoms like the chest pain and fatigue that are often associated with depression. On the other hand, psychotherapy seemed to reveal changes in frontal and temporal cortex – the parts of our brain that control thoughts and memories. Researchers determined that these two unique effects form a contrasting, but complementary effect.  For example, an individual with fewer physical symptoms might be less likely to sink into a deeper depression, and someone with fewer negative thought patterns might be less likely to develop physical symptoms of depression.

On the whole, a significant body of research supports a combination of psychotherapy and medication. Studies show that medication treatment as an adjunct to psychotherapy leads to longer-lasting remediation of symptoms. The theory is that the combination of medications and talking treatments has the effect of ‘revising’ parts of the brain to a mode similar to what we would see in individuals who are not depressed.

a glass bottle with pills inside and out over a light blue background

In particular, Cognitive Behavioral Therapy has been noted as a vital tool in stimulating adaptive brain function patterns. A Kings College London study found that CBT led to heightened brain connectivity and long-term remission of symptoms. Over a period of six months of therapy, researchers found that the connection between key brain regions became stronger in a significant number of study participants. CBT targets anxiety, depression, and other mental illnesses by helping you to identify negative thought patterns and to replace them with healthy ones.

Specifically, the scans revealed heightened connections in the part of the brain associated with fear, reasoning and thinking rationally, which, in theory, can help a person to more accurately assess social threats and reduce unnecessary anxiety. In essence, rewriting thought patterns can help us to rewrite our brains.

On the surface, psychotherapy may simply seem to be talking about your concerns and symptoms in a supportive environment – but the truth is, the effect is much deeper.  Thoughts become feelings, which, in turn, lead to behaviors.  Identifying and changing thought patterns and beliefs is a powerful way to initiate long-lasting life changes.  If you’re dealing with depression or anxiety, medication may be an effective way to increase the benefits of psychotherapy. The good news is therapy in and of itself can help to change brain activity and reverse the imbalances that contribute to a depression.

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About Dr. Lewis

Dr. Lewis

Dr. Beata Lewis is quadruple board-certified in adult psychiatry, child & adolescent psychiatry, integrative medicine, and integrative holistic medicine, with over 20 years of clinical experience. She founded Mind Body Psychiatry group practices in New York. Beyond her clinical work, Dr. Lewis is an active educator and leader in the field of integrative psychiatry. She is licensed to practice in New York, California, and New Jersey.

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Related Topics

  • Integrating Mindfulness and Psychotherapy for Better Results
  • How Therapy Goals Are Set and Measured
  • Psychotherapy for Teens vs Adults: Key Differences
  • How to Choose the Right Therapist in New York
  • Common Myths About Psychotherapy Debunked
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Author

Beata "Bliss" Lewis, M.D.

Owner

I'm Dr. Beata "Bliss" Lewis, a Harvard-trained psychiatrist specializing in integrative approaches to mental health. I blend traditional psychiatry with functional medicine, incorporating psychotherapy, medications, supplements, functional lab testing, mind-body techniques, and lifestyle interventions to treat the whole person. My training includes adult psychiatry at Columbia and child psychiatry at NYU Child Study Center, with advanced certifications in functional and integrative medicine. I specialize in anxiety, depression, ADHD, and trauma. As a mother of twin elementary school girls, I stay connected to the everyday realities families face.

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